More than 20 churches and religious organizations of many different affiliations serve the spiritual needs of downtown residents. Some churches, such as the First Presbyterian Church and Trinity Episcopal Church are among downtown's most historic places, dating back to the 1820's.

Calvary Fellowship
412 East Tombigbee Street
Florence, AL 35630
256.766.7640

College View Church of Christ
851 North Pine Street
Florence, AL 35630
256.766.0403

Eastside Church of Christ
600 East Tombigbee Street
Florence, AL 35630
256.766.2803

First Baptist Church
316 East Tombigbee Street
Florence, AL 35630
256.764.4921

First Christian Church
Disciples of Christ
700 North Wood Avenue
Florence, AL 35630
256.764.2192

First Presbyterian Church
224 East Mobile Street
Florence, AL 35630
256.764.2081

First United Methodist Church
415 North Seminary Street
Florence, AL 35630
256.764.5072

Greater Saint Paul AME Church
141 South Cherokee Street
Florence, AL 35630
256.764.3900

Lighthouse Ministries
921 West Mobile Street
Florence, AL 35630
256.760.1665

Mount Moriah Primitive Baptist Church
820 West Irvine Avenue
Florence, AL 35630
256.765.0312

Our Redeemer Lutheran Church
630 North Poplar Street
Florence, AL 35630
256.764.3902

Saint James Missionary Baptist Church
325 Wallace Street
Florence, AL 35630
256.764.0931

Saint Joseph Catholic Church
1111 East College Street
Florence, AL 35630
256.764.3303

Strait Gate Apostolic Church
812 East Tuscaloosa Street
Florence, AL 35630
256.740.0994

Tabernacle Baptist Church
211 South Poplar Street
Florence, AL 35630
256.767.2133

Temple Bnai Israel
201 East Hawthorne
Florence, AL 35630
256.764.9242

Tennessee Valley Community Church
119 North Pine Street
Florence, AL 35630
256.766.8620

The Ark
310 North Pine Street
Florence, AL 35630
256.764.7771

Trinity Episcopal Church
410 North Pine Street
Florence, AL 35630
256.764.6149

Wood Avenue Church of Christ
400 North Wood Avenue
Florence, AL 35630
256.764.9642